Deamino-histidine CAS: 1074-59-5
MF: C6H8N2O2
MW: 140.14

Deamino-histidine (CAS 1074-59-5)

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Alternate Names: Deamino-histidine is also known as Imidazolepropionic acid.
Application: Deamino-histidine is a histidine metabolite, potentially involved in oxidation or transamiination processes.
CAS Number: 1074-59-5
Purity: ≥98%
Molecular Weight: 140.14
Molecular Formula: C6H8N2O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Deamino-histidine is a histidine metabolite, potentially involved in oxidation or transamiination processes. Deamino-histidine is an inducer of the histidine-utilization system in Salmonella typhimurium. Deamino-histidine is able to inhibit the organism′s growth on succinate minimal medium. Studies using 2,3,5-triphenyl tetrazolium chloride plates to examine amino acid catabloism have shown that accumulation of Deamino-histidine may lead to inactivation of aspartate aminio-transferase.


参考文献

1. Bochner, B.R., Savageau, M.A. Inhibition of growth by imadazol(on)e propionic acid: Evidence in vivo for coordination of histidine catabolism with the catabolism of other amino acids. Molec. Gen. Genet. 168, 87–95 (1979). https://doi.org/10.1007/BF00267937

Physical State :
Solid
Storage :
Store at -20° C
Boiling Point :
427.4° C at 760 mmHg (Predicted)
Density :
1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted, tautomer)
IC50 :
Geotrichum candidum Histidinol dehydrogenase: IC50 = 3170 nM; GABA-A receptor; anion channel: IC50 = 290 µM (rat)
pK Values :
pKa: 4.14 (Predicted), pKb: 7.45 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL Number :
MFCD00237415
EC Number :
214-045-0
SMILES :
C1=C(NC=N1)CCC(=O)O

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Citations 1 to 2 of 2 total

PMID: # 30401435  Koh, A. et al. 2018. Cell. 175: 947-961.e17.

PMID: # 27221022  Tschirner, SK. et al. 2016. Life Sci. 156: 68-73.

Citations 1 to 2 of 2 total
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