Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DAAM1 Antibody (WW-3) is a high quality monoclonal DAAM1 antibody (also designated DAAM1 antibody) suitable for the detection of the DAAM1 protein of mouse, rat and human origin. DAAM1 Antibody (WW-3) is available as the non-conjugated anti-DAAM1 antibody. DAAM1 (dishevelled associated activator of morphogenesis 1) is a 1,078 amino acid member of the Formin homology protein family. Localized to the perinuclear cytoplasm and expressed throughout the body, DAAM1 binds to disheveled (Dvl) and Rho and mediates the Wnt-induced formation of the Dvl-Rho complex. Once complexed to Dvl, Rho becomes activated and can regulate cell polarity, movement and cytoskeletal architecture. Activation of Rho is dependent upon formation of the Dvl-Rho complex. This suggests that DAAM1 (which is required for complex formation) is a critical component of cellular cortex functions. DAAM1 contains several binding domains which allow it to interact with various proteins such as CIP4, FNBP1 and spectrin, thereby helping to coordinate the dynamics of the actin filament system. Additionally, DAAM1 is thought to act as a scaffolding protein by recruiting Rho-GEF and Rho-GDP, thus enhancing Rho-GTP formation. Three distinct isoforms exist due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.