Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cyclophilin E Antibody (9E18) is a high quality monoclonal Cyclophilin E antibody (also designated PPIE antibody) suitable for the detection of the Cyclophilin E protein of mouse, rat and human origin. Cyclophilin E Antibody (9E18) is available as the non-conjugated anti-Cyclophilin E antibody. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Cyclophilin E, also known as CyPE, Cyclophilin 33, CyP33, PPIase E or Rotamase E, is a ubiquitously expressed nuclear RNA-binding cyclophilin. It contains an N-terminal RNA binding domain (RRM) and a C-terminal cyclophilin domain. Cyclophilin E specifically binds to mRNA and, in accordance with this binding, the PPIase activity of Cyclophilin E is stimulated. In addition, Cyclophilin E can bind to the third PHD zinc finger domain of MLL (myeloid/lymphoid or mixed-lineage leukemia protein) and modify the effects of MLL on target genes. More specifically, the overexpression of Cyclophilin E is known to negatively regulate/inhibit the transcription of HoxC8 and HoxC9 genes. This inhibition occurs via the ability of Cyclophilin E to increase HDAC1 binding to the repression domain of MLL.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.