Curcumin (Synthetic) CAS: 458-37-7
MF: C21H20O6
MW: 368.38
Reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators.

Curcumin (Synthetic) (CAS 458-37-7)

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Application: Curcumin (Synthetic) is reported to suppress COX-1, COX-2, NF-κB and other inflammatory mediators
CAS Number: 458-37-7
Purity: ≥95%
Molecular Weight: 368.38
Molecular Formula: C21H20O6
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Curcumin (Synthetic), a phenolic pigment originally isolated from Curcuma longa (tumeric) has reported antioxident, anticancer and anti-inflammatory actvities as noted in multiple in vitro studies. A study investigating the effects of curcumin on reported inflammatory mediators in inflammatory bowel disease on colonic myofibroblasts obtained ex vivo reported that a dose-dependent suppression of matrix metalloproteinase-3 (MMP-3) occured. Additional studies report that Curcumin is able to suppress NF-κB, COX-1, COX-2 and TNF-α. Noted in research studies to upregulate PPARγ, p53 and Nrf2. Curcumin (Synthetic) is an inhibitor of 5-LO, Cox-2, CREB Binding Protein, GST, IKK, JNK, NF kappa B, NOS2, NQO1 and p300. Curcumin has been shown to modify histones. In one study, exposure of MCF7 cells to curcumin resulted in increased global levels of acetylated H3K18 and H4K16.


参考文献

1. Asai, A. and Miyazawa, T. 2001. J. Nutr. 131: 2932-2935. PMID: 11694621
2. Hanai, H. and Sugimoto, K. 2009. Curr. Pharm. Des. 15: 2087-2094. PMID: 19519446
3. Epstein, J., et al. 2010. Br. J. Nutr. 103: 824-832. PMID: 19878610
4. Shehzad, A., et al. 2011. Eur J Nutr. [Epub ahead of print]. PMID: 21442412

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
186° C
Boiling Point :
591.36° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
pK Values :
pKa: 8.11 (Predicted)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
RTECS :
MI5230000
PubChem CID :
MDL Number :
MFCD00008365
EC Number :
207-280-5
Beilstein Registry :
2306965
SMILES :
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

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Citations 1 to 3 of 3 total

PMID: # 33211286  Armağan, HH.|Nazıroğlu, M.| et al. 2020. Neurotox Res.

PMID: # 29740418  Simpson, S. et al. 2018. Front Microbiol. 9: 788.

PMID: # 22847000  Narayanan, A. et al. 2012. The Journal of biological chemistry. 287: 33198-214.

Citations 1 to 3 of 3 total
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