Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
Mammalian serine hydroxymethyltransferase (SHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate in the cytoplasm (cSHMT, SHMT1) and mitochondria (mSHMT, SHMT2). cSHMT preferentially supplies one-carbon units for thymidylate biosynthesis, depletes methylenetetrahydrofolate pools for S-adenosylmethionine (SAM) synthesis by synthesizing serine, sequesters 5-methyltetrahydrofolate, and inhibits SAM synthesis. Sheep liver cytosolic recombinant SHMT (scSHMT) Lys-71, Arg-80 and Asp 89 residues influence intra-subunit ionic interactions essential for catalytic activity; Tyr 72, Asp 227 and His-356 residues in the active site interact with PLP and maintain the tetrameric structure. Human cSHMT and mSHMT genes map to 17p11.2 and 12q13, respectively. The cDNA for the mitochondrial enzyme encodes a mature protein of 474 residues.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | SHMT1 | 6470 | 17p11.2 | XM_005256767, XM_011523992, XM_017024957, XM_017024958, XM_017024959, XM_017024960, NM_001281786, NM_004169, NM_148918 | P34896 | 182144 |