CRMP-2 抗体 (1B1): sc-101348

CRMP-2 Antibody (1B1) is an IgG_2a mouse monoclonal CRMP-2 antibody (also designated DPYL2 antibody, Dihydropyrimidinase Like 2 antibody, CRMP2 antibody, DRP-2 antibody, Dihydropyrimidinase-Related Protein 2 antibody, Unc-33-Like Phosphoprotein 2 antibody, DHPRP2 antibody, ULIP-2 antibody, ULIP2 antibody, DRP2 antibody, N2A3 antibody, Collapsin Response Mediator Protein HCRMP-2 antibody, or Collapsin Response Mediator Protein 2 antibody) that detects the CRMP-2 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). CRMP-2 Antibody (1B1) is available as the non-conjugated anti-CRMP-2 antibody. Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-2 is involved in axonal growth and guidance. The human CRMP-2 gene maps to 8p21.2, a chromosomal region that has been previously shown to have a significant linkage to schizophrenia and to several deficit symptoms of schizophrenia.

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References:

1. Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene.  |  Kitamura, K., et al. 1999. DNA Res. 6: 291-7. PMID: 10574455
2. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.  |  Gu, Y., et al. 2000. Biochemistry. 39: 4267-75. PMID: 10757975
3. The human dihydropyrimidinase-related protein 2 gene on chromosome 8p21 is associated with paranoid-type schizophrenia.  |  Nakata, K., et al. 2003. Biol Psychiatry. 53: 571-6. PMID: 12679234
4. Subcellular localization of collapsin response mediator proteins to lipid rafts.  |  Rosslenbroich, V., et al. 2003. Biochem Biophys Res Commun. 305: 392-9. PMID: 12745088
5. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons.  |  Quach, TT., et al. 2004. Mol Cell Neurosci. 25: 433-43. PMID: 15033171
6. Dihydropyrimidinase-related protein 2 (DRP-2) gene and association to deficit and nondeficit schizophrenia.  |  Hong, LE., et al. 2005. Am J Med Genet B Neuropsychiatr Genet. 136B: 8-11. PMID: 15858820