COX6b1 抗体 (77.1): sc-100524

The cytochrome c oxidase (COX) family of proteins function as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, ultimately resulting in the production of water. The mammalian COX apoenzyme is a dimer, with each monomer consisting of 13 subunits, some of which are mitochondrial and some of which are nuclear. COX6b1 (cytochrome c oxidase subunit VIb polypeptide 1) is a nuclear encoded subunit. Localizing to the intermatrix side of the inner membrane of the mitochondrion, COX6b1 is responsible for joining the two COX monomers to form the COX dimer. COX6b1 is highly expressed in oocytes and zygotes and appears to be unnecessary for early embryonic development but essential for the blastocyst stage. The loss or silencing of the gene encoding COX6b1 results in mitochondrial dysfunction that ultimately leads to apoptosis of blastocyst-stage embryos.