CH 223191 CAS: 301326-22-7
MF: C19H19N5O
MW: 333.39
A potent and specific aryl hydrocarbon receptor inhibitor.

CH 223191 (CAS 301326-22-7)

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Alternate Names: 1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phen yl-1H-pyrazole-5-carboxamide; AhR Antagonist
Application: CH 223191 is a potent and specific aryl hydrocarbon receptor inhibitor
CAS Number: 301326-22-7
Purity: ≥95%
Molecular Weight: 333.39
Molecular Formula: C19H19N5O
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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CH 223191 is shown to be a potent 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-induced aryl hydrocarbon receptor inhibitor. Mechanistic experiments show that CH 223191 blocks binding of TCDD to AhR and prevents TCDD-mediated nuclear translocation and AhR DNA binding. Detailed studies show that CH 223191 specifically prevents expression of cytochrome P450 enzyme, which is the target gene of AhR. AhR is a transcription factor that mediates cell cycle progression and affects transforming growth factor-β (TGF-β) signaling.


参考文献

1. Kim, S.H., et al. 2006. Mol. Pharmacol. 69: 1871-1878. PMID: 16540597
2. Veldhoen, M., et al. 2009. J. Exp. Med. 206: 43-49. PMID: 19114668
3. Gramatzki, D., et al. 2009. Oncogene. 28: 2593-2605. PMID: 19465936

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (10 mM).
Storage :
Store at 4° C
Melting Point :
223.62° C(Mean or Weighted MP)
Boiling Point :
~469.43° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63
IC50 :
TCDD-induced AhR transcription activity: IC50 = 30 nM (HepG2 cells)
仅供科研使用。不可用于诊断或治疗。
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00377884
SMILES :
CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C

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Citations 1 to 2 of 2 total

PMID: # 31350436  Sci Rep. 10878.

PMID: # 27543265  Mol. Cell. Endocrinol. 437: 190-200.

Citations 1 to 2 of 2 total
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