Celastramycin A CAS: 491600-94-3
MF: C17H18Cl3NO3
MW: 390.7
A bioactive compound isolated from endophytic bacteria.

Celastramycin A (CAS 491600-94-3)

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Alternate Names: (3-chloro-5-hexyl-2,6-dihydroxyphenyl)(4,5-dichloro-1H-pyrrol-3-yl)-methanone
Application: Celastramycin A is a bioactive compound isolated from endophytic bacteria
CAS Number: 491600-94-3
Molecular Weight: 390.7
Molecular Formula: C17H18Cl3NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Celastramycin A is a bioactive compound isolated from endophytic bacteria living in plants of the Celastraceae family. This benzoyl pyrrole inhibits the growth of bacteria and mycobacteria, with a minimal inhibitory concentration as low as 0.05 μg/ml. Celastramycin A also suppresses the production of interleukin-8 in human umbilical vein endothelial cells as stimulated by tumor necrosis factor-α (IC50 = 0.01 μg/ml).


参考文献

1 Pullen, C., Schmitz, P., Meurer, K., et al. New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta 216 162-167 (2002). 2 Kikuchi, H., Sekiya, M., Katou, Y., et al. Revised structure and synthesis of Celastramycin A, a potent innate immune suppressor. Organic Lett 11(8) 1693-1695 (2009).

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1:4 ethanol:PBS(pH 7.2) (~0.2 mg/ml).
Storage :
Store at -20° C
Melting Point :
218.29° C (Predicted)
Boiling Point :
516.47° C at 760 mmHg (Predicted)
Density :
~1.41 g/cm3 (Predicted)
Refractive Index :
n20D ~1.62 (Predicted)
IC50 :
Suppress the production of interleukin-8: IC50 = 0.01 µg/ml (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD16876177
SMILES :
ClC1=CC(CCCCCC)=C(O)C(C(C2=CC(Cl)=C(Cl)N2)=O)=C1O

Download SDS (MSDS)

Certificate of Analysis

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