Date published: 2025-9-6
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CD3 Antibody (17A2) - Immunofluorescence - Image 4694
CD3 抗体 (17A2): sc-18843. 甲醇固定的 CTLL-2 细胞免疫荧光染色, 显示膜染色.
CD3 抗体 (17A2): sc-18843. 甲醇固定的 CTLL-2 细胞免疫荧光染色, 显示膜染色.

CD3 抗体 (17A2): sc-18843

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寫評論提問

说明书
  • CD3 抗体 17A2 是大鼠单克隆 IgG2b, 在12篇文献中引用，提供 200 µg/ml
  • 针对γδ TCR阳性T-T杂交瘤D1细胞，来自mouse来源
  • 推荐用于 mouse 来源的CD3 IP, IF 和 FCM检测
  • 还可偶联FITC 用于IF, IHC(P) 和FCM
  • 看 CD3 (PC3/188A): sc-20047，可查看有标记的 CD3 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成CD3 抗体 (17A2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CD3 抗体包括 CD3-δ, CD3-ε, CD3-γ 和 CD3-ζ

CD3抗体（17A2）是一种鼠单克隆IgG2b抗体，用于识别小鼠CD3，推荐用于免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）等实验。CD3也称为T细胞共受体复合物或TCR-CD3复合物，位于T淋巴细胞表面，在T细胞受体（TCR）信号传导中发挥关键作用。这种定位对于T细胞的激活和调节至关重要，使T细胞能够对外来抗原做出有效反应。CD3复合物由五个不变的多肽链组成，分别是伽马、伊普西隆、德尔塔、泽塔和埃塔，它们形成三个不同的二聚体，每个二聚体都包含免疫受体酪氨酸基激活基序（ITAM）。这些ITAM对于启动细胞内信号级联至关重要，它们通过招募ZAP-70和Syk等蛋白激酶来激活T细胞并促进其增殖。通过靶向CD3复合物，抗CD3抗体（17A2）使研究人员能够研究T细胞激活、信号转导和免疫反应机制。CD3单克隆抗体（17A2）与小鼠细胞上的CD3结合，使CD3（17A2）抗体成为免疫学研究不可或缺的工具，能够对各种实验条件下的T细胞功能和调节进行详细分析。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

CD3 抗体 (17A2)

sc-18843
200 µg/ml
RMB2377.00

CD3 抗体 (17A2) FITC

sc-18843 FITC
200 µg/ml
RMB2482.00

Can CD3(17A2) be used in FACS followed by T cell functional studies? Will it activate T cells or have no effect on T cells? Could all CD3 antibodies activate T cells? Thank you so much!!!

Asked by: Esther
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Can CD3 (17A2): sc-18843 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD3 (17A2): sc-18843 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Good in Flow cytometrywe used the antibody in Flow cytometry for primary mouse spleen cells, and it's good, but not better than BD's CD3 antibody.
Date published: 2016-12-20
Rated 4 out of 5 by from Wonderful immunofluorescence membrane stainingWonderful immunofluorescence membrane staining in methanol-fixed CTLL-2 cells. -SCBT QC
Date published: 2015-04-30
Rated 4 out of 5 by from Published IHC(pfa) data for use in mousePublished IHC(pfa) data for use in mouse sciatic nerves,nerve roots, spinal cord posterior column samples. -SCBT Publication Review
Date published: 2015-01-21
Rated 4 out of 5 by from Produced good FCM data for mouse peripheralProduced good FCM data for mouse peripheral blood leukocytes. -SCBT QC
Date published: 2013-01-26
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CD3 抗体 (17A2) is rated 4.0 out of 5 by 4.
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