CD 2665 CAS: 170355-78-9
MF: C31H34O5
MW: 486.60
A selective RARβ/γ antagonist.

CD 2665 (CAS 170355-78-9)

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Alternate Names: 4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic acid
Application: CD 2665 is a selective RARβ/γ antagonist
CAS Number: 170355-78-9
Purity: >98%
Molecular Weight: 486.60
Molecular Formula: C31H34O5
仅供科研使用。不可用于诊断或治疗。
Available in US only.
* 参考分析证明 大量特定数据 (包括水 含量).
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CD 2665 is a selective RARβ/γ antagonist (KD values are 110, 306 and > 1000 nM for RARγ, RARβ and RARα respectively). CD 2665 is shown to block retinoic acid-induced apoptosis ex vivo.


参考文献

Szondy et al (1997) Induction of apoptosis by retinoids and retinoic acid receptor g-selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol.Pharmacol. 51 972. Meister et al (1998) Antiproliferative activity and apoptosis induced by retinoic acid receptor-gamma selectivity binding retinoids in neuroblastoma. Anticancer Res. 18 1777. Kim et al (2000) The role of specific retinoid receptors in sebocyte growth and differentiation in culture. J.Invest.Dermatol. 114 349.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
275.27° C (Predicted)
Boiling Point :
~668.6° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
仅供科研使用。不可用于诊断或治疗。
Available in US only.
PubChem CID :
MDL Number :
MFCD13176719
SMILES :
COCCOCOC1=C(C=C2C=C(C=CC2=C1)C3=CC=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5

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Citations 1 to 2 of 2 total

PMID: # 30986261  García-Sánchez, A.|Marcos-Vadillo, E.|Sanz, C.|Estravís, M.|Isidoro-García, M.|Dávila, I.| et al. 2019. PLoS One. 14: e0215086.

PMID: # 32075739  Cell Rep.

Citations 1 to 2 of 2 total
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