Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US, Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxesShips via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items
CARF Antibody (14.4) is a high quality monoclonal CARF antibody (also designated CARF antibody) suitable for the detection of the CARF protein of human origin. CARF Antibody (14.4) is available as the non-conjugated anti-CARF antibody. CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell. Mutations in the gene encoding CARF may by implicated in familial amyotrophic lateral sclerosis 2, a fatal neurodegenerative disease that is characterized by upper and lower motor neuron damage. Two isoforms of CARF exist due to alternative splicing events.
种属 | 基因名称 | 基因ID | 染色质位置 | 亚型(mRNA)即位号码 | 蛋白质即位号码 | OMIM™ 号码 |
---|---|---|---|---|---|---|
Human | CARF | 79800 | 2q33.2 | XM_005246858, XM_005246859, XM_005246864, XM_006712760, XM_011511867, XM_011511868, XM_011511869, XM_017004961, XM_017004962, XM_017004963, XM_017004964, XM_017004965, XM_017004966, NM_001104586, NM_001282910, NM_001282911, NM_001282912, NM_001322427, NM_001322428, NM_001322429, NM_001322430, NM_024744 | Q8N187 | 607586 |