CARF 抗体 (14.4): sc-101206

CARF Antibody (14.4) is an IgG_2a κ mouse monoclonal CARF antibody (also designated CARF antibody) suitable for the detection of the CARF protein of human origin by WB, IP, IF and ELISA. CARF Antibody (14.4) is available as the non-conjugated anti-CARF antibody. CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell. Mutations in the gene encoding CARF may by implicated in familial amyotrophic lateral sclerosis 2, a fatal neurodegenerative disease that is characterized by upper and lower motor neuron damage. Two isoforms of CARF exist due to alternative splicing events.