Cardamonin CAS: 19309-14-9
MF: C16H14O4
MW: 270.28

Cardamonin (CAS 19309-14-9)

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Alternate Names: (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one; Alpinetin chalcone
CAS Number: 19309-14-9
Purity: ≥98%
Molecular Weight: 270.28
Molecular Formula: C16H14O4
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Cardamonin is a chalone analog that display anti-inflammatory activity. Has been shown to inhibit NO and PGE2 production from LPS- and IFN-γ-induced RAW cells and inhibits TXB2 production via the COX-1 and COX-2 pathways. Also has been shown to inhibit NF-κB activation


参考文献

Lee et al (2006) Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of Cardamomin, a chalcone analog from Alpina conchigera. J.Pharmacol.Exp.Ther. 316 271. Ahmad et al (2006) Cardamonin, inhibits pro-inflammatory mediators in a

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
Storage :
Store at 4° C
Melting Point :
195-196° C
Boiling Point :
~484.5° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
KV1.3: IC50 = 2 nM (human); DLD-1: IC50 = 41.8 µM (human)
Ki Data :
Dengue virus type 2 NS3 protein: Ki= 377 µM
pK Values :
pKa: 7 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL Number :
MFCD00238554
SMILES :
COC1=CC(=CC(=C1C(=O)/C=C/C2=CC=CC=C2)O)O

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Certificate of Analysis

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