Calpain Inhibitor VI CAS: 190274-53-4
MF: C17H25FN2O4S
MW: 372.5

Calpain Inhibitor VI (CAS 190274-53-4)

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Alternate Names: Calpain Inhibitor VI is also known as SJA 6017.
Application: Calpain Inhibitor VI is a potent and reversible inhibitor of the calcium-dependent cysteine proteases µ-calpain and m-calpain.
CAS Number: 190274-53-4
Purity: ≥95%
Molecular Weight: 372.5
Molecular Formula: C17H25FN2O4S
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Calpain Inhibitor VI is a cell permeable peptide aldehyde which functions as a reversible calpain inhibitor. Studies indicate that Calpain Inhibitor VI strongly inhibits cathepsin B and cathepsin L. In addition, Calpain Inhibitor VI reduces nuclear opacity and proteolysis of crystallins and α-spectrin induced by A23187 (sc-3591). Studies suggest that substitution at the P1 position, specially a bulky amino acid residual aldehyde, will increase the potency of the Calpain Inhibitor VI. Furthermore, the S-configuration of Calpain Inhibitor VI is important in the inhibition of cathepsin L.


参考文献

1. Inoue, J. et al. 2003. J. Med. Chem. 46(5): 868-871. PMID: 12593666

2. Andley, U.P. 2007. Prog Retin Eye Res. 26(1): 78-98. PMID: 17166758

3. Kupina, N.C. et al. 2001. J. Neurotrauma. 18(11): 1229-1240. PMID: 11721741

Physical State :
Solid
Sequence :
4-Fluorophenylsulfonyl-Val-Leu-CHO
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
218.69° C (Predicted)
Boiling Point :
513.04° C (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
µ-calpain: IC50 = 7.5 nM; m-calpain: IC50 = 78 nM; cathepsin B: IC50 = 15 nM; cathepsin L: IC50 = 1.6 nM
pK Values :
pKa: 9.04 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL Number :
MFCD00954660
SMILES :
CC(C)C[[email protected]@H](C=O)NC(=O)[[email protected]](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F

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Citations 1 to 3 of 3 total

PMID: # 21986493  Pnueli, L. et al. 2011. Mol. Cell. Biol. 31: 5023-36.

PMID: # 29718706  FASEB J. 5312-5325.

PMID: # 30496824  Neuroscience. 397: 159-171.

Citations 1 to 3 of 3 total
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