C 021 dihydrochloride CAS: 1784252-84-1
MF: C27H41N5O2•2HCl
MW: 540.57

C 021 dihydrochloride (CAS 1784252-84-1)

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Alternate Names: 2-[1,4′-Bipiperidin]-1′-yl-N-cycloheptyl-6,7-dimethoxy-4-quinazolinamine dihydrochloride
CAS Number: 1784252-84-1
Purity: ≥99%
Molecular Weight: 540.57
Molecular Formula: C27H41N5O22HCl
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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A potent CCR4 chemokine receptor antagonist (IC50 values are 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively)


参考文献

Yokoyama et al (2009) Potent and orally bioavailable CCR4 antagonists: synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg.Med.Chem. 17 64.

Physical State :
Solid
Solubility :
Soluble in water (50 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
IC50 :
CCR4 chemokine receptor: IC50 = 0.14 µM (human); CCR4 chemokine receptor: IC50 = 0.039 µM (mouse); CCL22-binding: IC50 = 73 nM; CCL22-induced GTPγS recruitment: IC50 = 18 nM
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
MDL Number :
MFCD16618393
SMILES :
COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCC(CC3)N4CCCCC4)NC5CCCCCC5)OC.Cl.Cl

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Certificate of Analysis

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