BRMS1 抗体 (4H7): sc-101219

BRMS1 Antibody (4H7) is an IgG₁ κ mouse monoclonal BRMS1 antibody (also designated BRMS1 antibody) suitable for the detection of the BRMS1 protein of human origin by WB, IP and ELISA. BRMS1 Antibody (4H7) is available as the non-conjugated anti-BRMS1 antibody. Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NFκB activity.

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References:

1. Breast cancer metastasis suppressor 1: update.  |  Meehan, WJ. and Welch, DR. 2003. Clin Exp Metastasis. 20: 45-50. PMID: 12650606
2. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription.  |  Meehan, WJ., et al. 2004. J Biol Chem. 279: 1562-9. PMID: 14581478
3. Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases.  |  Stark, AM., et al. 2005. J Cancer Res Clin Oncol. 131: 191-8. PMID: 15592684
4. Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells.  |  DeWald, DB., et al. 2005. Cancer Res. 65: 713-7. PMID: 15705865
5. Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity.  |  Cicek, M., et al. 2005. Cancer Res. 65: 3586-95. PMID: 15867352
6. Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1).  |  Samant, RS., et al. 2006. Cancer Lett. 235: 260-5. PMID: 15978719
7. Expression of the breast cancer metastasis suppressor gene, BRMS1, in human breast carcinoma: lack of correlation with metastasis to axillary lymph nodes.  |  Kelly, LM., et al. 2005. Tumour Biol. 26: 213-6. PMID: 16006775
8. Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.  |  Hurst, DR., et al. 2006. Biochem Biophys Res Commun. 348: 1429-35. PMID: 16919237
9. [Progress on breast cancer metastasis suppressor 1 (BRMS1)].  |  Yuan, Y., et al. 2006. Yi Chuan. 28: 1141-8. PMID: 16963426