Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
BRIDGE-1 Antibody (ZZ07) is a high quality monoclonal BRIDGE-1 antibody (also designated BRIDGE-1 antibody) suitable for the detection of the BRIDGE-1 protein of mouse, rat and human origin. BRIDGE-1 Antibody (ZZ07) is available as the non-conjugated anti-BRIDGE-1 antibody. BRIDGE-1, a protein homologous to a previously cloned proteasome subunit p27 is important in regulating Insulin and other islet genes in the pancreas. BRIDGE-1 is highly expressed in pancreatic b-cells and is predominantly located in the nucleus, although lower levels are expressed in the cytoplasm. BRIDGE-1 contains a conserved PDZ-like domain that mediates protein-protein interactions in a variety of intracellular signaling processes, including the transactivational activity of E2A. One mechanism of the activation of gene transcription in pancreatic b-cells is the interaction of E2A with coactivating proteins such as CBP, p300 and BRIDGE-1. The interaction of E12 and E47, members of the E2A family of transcription factors, with the PDZ-domain of BRIDGE-1 suggest a novel mechanism for Insulin gene regulation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with BRIDGE-1 (ZZ07): sc-100996 antibody?
Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.