BAIAP2L1 抗体 (A-14): sc-100680

BAIAP2L1 (Brain-specific angiogenesis inhibitor 1-associated protein 2-like 1), also known as IRTKS (insulin receptor tyrosine kinase substrate), is a widely expressed, 511 amino acid protein with predominant expression in liver, testis, bladder, lung and heart. It contains one IMD (IRSp53/MTSS1 homology) domain, one SH3 domain and a C-terminal region that is similar to a WH2 domain. Other proteins containing the IMD domain, such as IRSp53 and MTSS1, are known to participate in actin filament bundling and induction of filopodia-like protrusions. BAIAP2L1 is closely related to IRSp53 but, unlike the filopodia-like protrusions caused by IRSp53, expression of BAIAP2L1 results in short actin clusters around the peripherary of the cell. Similar to IRSp53, BAIAP2L1 is a substrate for the insulin receptor (insulin R) and undergoes tyrosine phosphorylation upon stimulation with insulin. In addition, BAIAP2L1 is capable of binding Rac via its N-terminal IMD domain.