Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Bag-2 (Bcl-2-associated athanogene 2), also known as Bag family molecular chaperone regulator 2, is a member of the Bag family of proteins and contains the most diverged of the characteristic C-terminal Bag domain. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-2 is an evolutionarily conserved cytoplasmic protein with putative N-terminal phosphorylation sites and specifically functions as an HSC 70 co-chaperone. Bag-2 is a major component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to disrupt CHIP-mediated ubiquitylation. In this complex, Bag-2 directly interacts with the ATPase domain of HSC 70 as well as the U-box domain of CHIP and inhibits ubiquitylation by interfering with the association between CHIP and its ubiquitin conjugating enzyme.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with Bag-2 (A-12): sc-101216 antibody?
Asked by: Germaine
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.