Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ARH (autosomal recessive hypercholesterolemia protein), also known as LDLRAP1 (low density lipoprotein receptor adapter protein 1), is a 308 amino acid cytoplasmic protein that contains one PID domain. ARH is an adapter protein required for efficient endocytosis of the LDL receptor (LDLR) from coated pits in polarized cells such as hepatocytes and lymphocytes. To do this, ARH acts to stabilize the interaction between the receptor and the structural components of the pits. While expressed at high levels in kidney, liver and placenta, ARH is expressed at low levels in brain, heart, muscle, colon, spleen, intestine, lung and leukocytes. Defects in the ARH gene are the cause of autosomal recessive hypercholesterolemia, a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. Autosomal recessive hypercholesterolemia has the clinical features of familial hypercholesterolemia (FH), including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.