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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
ANP32A Antibody (A-182) is a high quality monoclonal ANP32A antibody (also designated ANP32A antibody) suitable for the detection of the ANP32A protein of human origin. ANP32A Antibody (A-182) is available as the non-conjugated anti-ANP32A antibody. Protein phosphatase 2A PP2A is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. ANP32A, also known as Inhibitor 1 of PP2A (I1PP2A), and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. ANP32A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The ANP32A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms′ tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-100767: ANP32A (A-182) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: Cweed
Thank you for your question. Yes, sc-100767: ANP32A (A-182) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 5 out of
Great for detecting ANP32A in human samplesThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-02-01
Rated 5 out of
the good function of ANP32AImplicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. the function is good for the used human.
Date published: 2017-01-19
Rated 4 out of
Produced great immunoperoxidase nuclear stainingProduced great immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human tonsil tissue. -SCBT QC