Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
AFF4 (AF4/FMR2 family, member 4), also known as MCEF or AF5Q31, localizes to the nucleus and is a member of the AF4 family of transcription factors. Ubiquitously expressed with highest expression in placenta, heart, pancreas and skeletal muscle, AFF4 is a 1,163 amino acid component of the positive transcription elongation factor b (P-TEFb) complex that contains Cdk9 (cyclin-dependent kinase 9) and cyclin T1. AFF4 is thought to function as a transcription factor that positively regulates transcription during fetal development, as well as in adult tissue. Defects in the gene encoding AFF4 lead to expression of an MLL-AFF4 (myeloid/lymphoid or mixed-lineage leukemia-AFF4) fusion protein that is found in acute lymphoblastic leukemia (ALL), implicating AFF4 in the pathogenesis of ALL. Three isoforms of AFF4 are expressed due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-101062: AFF4 (3D2) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Asked by: Randy McDonald
Thank you for your question. Yes, sc-101062: AFF4 (3D2) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: