ADH6 抗体 (WW32): sc-100495

ADH6 Antibody (WW32) is an IgG_2a κ mouse monoclonal ADH6 antibody (also designated ADH6 antibody) that detects the ADH6 protein of human origin by WB, IP and ELISA. ADH6 Antibody (WW32) is available as the non-conjugated anti-ADH6 antibody. ADH6 (alcohol dehydrogenase 6), also known as ADH-5, is a 368 amino acid member of the class V zinc-containing alcohol dehydrogenase family. This family of enzymes functions to metabolize a wide variety of substrates such as retinol, hydroxysteroids, ethanol, aliphatic alcohols and lipid peroxidation products. Localized to the cytoplasm and expressed in the stomach and liver, ADH6 catalyzes the reversible oxidation of alcohols to their corresponding aldehydes or ketones and is able to bind two zinc ions as cofactors. ADH6 contains a glucocorticoid response element upstream of its 5′ UTR which is thought to be a steroid binding site, suggesting that expression of ADH6 may be under hormonal control. Multiple isoforms of ADH6 exist due to alternative splicing events.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. Mammalian alcohol dehydrogenase of higher classes: analyses of human ADH5 and rat ADH6.  |  Höög, J., et al. 2001. Chem Biol Interact. 130-132: 395-404. PMID: 11306061
2. A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversity.  |  Osier, MV., et al. 2002. Am J Hum Genet. 71: 84-99. PMID: 12050823
3. The mammalian alcohol dehydrogenases interact in several metabolic pathways.  |  Höög, JO., et al. 2003. Chem Biol Interact. 143-144: 175-81. PMID: 12604202
4. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence.  |  Luo, X., et al. 2006. Am J Hum Genet. 78: 973-87. PMID: 16685648
5. Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.  |  Luo, X., et al. 2007. Hum Mol Genet. 16: 380-90. PMID: 17185388
6. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene.  |  Chen, CS. and Yoshida, A. 1991. Biochem Biophys Res Commun. 181: 743-7. PMID: 1755855
7. A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme.  |  Yasunami, M., et al. 1991. Proc Natl Acad Sci U S A. 88: 7610-4. PMID: 1881901