ACTL7B 抗体 (K30): sc-100912

ACTL7B (actin-like 7B) is a member of the ARP family of actin-related proteins that contain an actin fold and are involved in spindle orientation, nuclear migration and chromatin remodeling events. Localized to the cytoplasm and expressed in the testis and prostate, ACTL7B is 415 amino acids in length and is encoded by a gene that is oriented in a head-to-head formation with the familial dysautonomia (FD) candidate region on chromosome 9. Although located in a region associated with FD, ACTL7B is not involved in the pathogenesis of the genetic disease. ACTL7B shares high sequence similarity with ACTL7A (actin-like 7A) and contains one conserved protein kinase C (PKC) site and one conserved cAMP/cGMP-dependent phosphorylation site. The human and mouse proteins share 88% sequence similarity.