4-Phenylbutyric acid CAS: 1821-12-1
MF: C10H12O2
MW: 164.20
A chemical chaperone that suppresses oxidative stress.

4-Phenylbutyric acid (CAS 1821-12-1)

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Alternate Names: 4-phenylbutanoic acid
Application: 4-Phenylbutyric acid is a chemical chaperone that suppresses oxidative stress
CAS Number: 1821-12-1
Molecular Weight: 164.20
Molecular Formula: C10H12O2
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

4-Phenylbutyric acid is a chemical chaperone, which suppresses oxidative stress by attenuating endoplasmic reticulum stress. 4-Phenylbutyric acid increases the expression of type 2 deiodinase (D2), via the accumulation of Dio2 mRNA. Studies indicate that 4-Phenylbutyric acid affects genes such as Ucp-1, Ucp-3 and Pgc-1α in a D2-dependent manner. The activation of these genes is thought to increase T3 production. Diabetic studies conducted on mice suggest that 4-Phenylbutyric acid normalizes serum glucose levels.


参考文献

1. Xu, T.Y., et al. 2010. Clin. Exp. Pharmacol. Physiol. 37: 441-446. PMID: 19878212
2. Luo, Z.F., et al. 2010. Toxicol. Appl. Pharmacol. 246: 49-57. PMID: 20399799
3. da-Silva, W.S., et al. 2011. FEBS Lett. 585: 539-544. PMID: 21237159

Appearance :
Powder or crystalline
Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
49-51° C (lit.)
Boiling Point :
165° C at 10 mmHg
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
4775
MDL Number :
MFCD00004403
EC Number :
217-341-8
Beilstein Registry :
638180
SMILES :
C1=CC=C(C=C1)CCCC(=O)O

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Citations 1 to 5 of 5 total

PMID: # 29458048  Park, HJ.|Son, HJ.|Sul, OJ.|Suh, JH.|Choi, HS.| et al. 2018. Biochem. Pharmacol. 151: 9-17.

PMID: # 26907328  Zhou, Y. et al. 2016. Viruses. 8:

PMID: # 22548801  Kim, HD. et al. 2012. Biochem. Biophys. Res. Commun. 422: 213-8.

PMID: # 31781343  Oxid Med Cell Longev. 2019: 6404035.

PMID: # 29468369  Diabetologia. 1220-1232.

Citations 1 to 5 of 5 total
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