Date published: 2025-11-7

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GP78-1 Inhibidores

GP78-1 inhibitors represent a specific chemical class of compounds designed to target the protein GP78-1, also known as RNF45. GP78-1 is an E3 ubiquitin ligase responsible for regulating protein quality control and degradation processes within the cell. Inhibiting GP78-1 activity is an area of active research to gain insights into the molecular pathways that govern protein degradation. These inhibitors are meticulously developed to interact with GP78-1 at a molecular level, with the aim of modulating its enzymatic function. By specifically disrupting GP78-1's activity, researchers seek to elucidate its role in cellular protein homeostasis and degradation.

The chemical structures of GP78-1 inhibitors can vary, and they are designed to interact with specific binding sites or domains of GP78-1, thus interfering with its ability to tag proteins for degradation. Investigating GP78-1 inhibitors is an essential endeavor to advance our understanding of the complex cellular mechanisms that govern protein turnover and ensure cellular integrity. Such research contributes to the broader knowledge of cellular processes and their regulation, with implications for various biological and disease-related contexts.

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Nombre del productoNÚMERO DE CAS #Número de catálogoCantidadPrecioMENCIONESClasificación

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
¥1264.00
¥2245.00
¥3915.00
¥7706.00
¥15073.00
¥64556.00
12
(1)

Este compuesto inhibe la ERAD al interferir con p97/VCP, un componente clave en la vía en la que interviene GP78.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
¥1670.00
104
(1)

Este inhibidor de UBE2N puede interrumpir la actividad de conjugación de la ubiquitina, afectando indirectamente a la función de GP78.

Clotrimazole

23593-75-1sc-3583
sc-3583A
100 mg
1 g
¥463.00
¥632.00
6
(2)

Conocido como inhibidor de la ATPasa p97/VCP, el clotrimazol podría influir en los procesos de ERAD mediados por GP78.

DBeQ

177355-84-9sc-499943
10 mg
¥3723.00
1
(0)

El DBeQ es un inhibidor selectivo de p97/VCP, que podría afectar a la vía ERAD en la que opera la GP78.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
¥1489.00
¥12004.00
115
(2)

Un inhibidor del proteasoma que podría afectar a los procesos posteriores de la actividad ubiquitina ligasa de GP78.

NMS-873

1418013-75-8sc-478803
5 mg
¥3385.00
(0)

El NMS-873, un potente inhibidor de p97/VCP, podría afectar indirectamente a la función de GP78 en la ERAD.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
¥1862.00
¥6487.00
60
(2)

Un inhibidor del proteasoma, que afecta a la vía ubiquitina-proteasoma, influyendo así indirectamente en GP78.

Carfilzomib

868540-17-4sc-396755
5 mg
¥451.00
(0)

Otro inhibidor del proteasoma, que podría afectar a la vía en la que interviene GP78.