GP78-1 inhibitors represent a specific chemical class of compounds designed to target the protein GP78-1, also known as RNF45. GP78-1 is an E3 ubiquitin ligase responsible for regulating protein quality control and degradation processes within the cell. Inhibiting GP78-1 activity is an area of active research to gain insights into the molecular pathways that govern protein degradation. These inhibitors are meticulously developed to interact with GP78-1 at a molecular level, with the aim of modulating its enzymatic function. By specifically disrupting GP78-1's activity, researchers seek to elucidate its role in cellular protein homeostasis and degradation.
The chemical structures of GP78-1 inhibitors can vary, and they are designed to interact with specific binding sites or domains of GP78-1, thus interfering with its ability to tag proteins for degradation. Investigating GP78-1 inhibitors is an essential endeavor to advance our understanding of the complex cellular mechanisms that govern protein turnover and ensure cellular integrity. Such research contributes to the broader knowledge of cellular processes and their regulation, with implications for various biological and disease-related contexts.
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| Nombre del producto | NÚMERO DE CAS # | Número de catálogo | Cantidad | Precio | MENCIONES | Clasificación |
|---|---|---|---|---|---|---|
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | ¥1264.00 ¥2245.00 ¥3915.00 ¥7706.00 ¥15073.00 ¥64556.00 | 12 | |
Este compuesto inhibe la ERAD al interferir con p97/VCP, un componente clave en la vía en la que interviene GP78. | ||||||
Stat3 Inhibitor VI, S3I-201 | 501919-59-1 | sc-204304 | 10 mg | ¥1670.00 | 104 | |
Este inhibidor de UBE2N puede interrumpir la actividad de conjugación de la ubiquitina, afectando indirectamente a la función de GP78. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | ¥463.00 ¥632.00 | 6 | |
Conocido como inhibidor de la ATPasa p97/VCP, el clotrimazol podría influir en los procesos de ERAD mediados por GP78. | ||||||
DBeQ | 177355-84-9 | sc-499943 | 10 mg | ¥3723.00 | 1 | |
El DBeQ es un inhibidor selectivo de p97/VCP, que podría afectar a la vía ERAD en la que opera la GP78. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | ¥1489.00 ¥12004.00 | 115 | |
Un inhibidor del proteasoma que podría afectar a los procesos posteriores de la actividad ubiquitina ligasa de GP78. | ||||||
NMS-873 | 1418013-75-8 | sc-478803 | 5 mg | ¥3385.00 | ||
El NMS-873, un potente inhibidor de p97/VCP, podría afectar indirectamente a la función de GP78 en la ERAD. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | ¥1862.00 ¥6487.00 | 60 | |
Un inhibidor del proteasoma, que afecta a la vía ubiquitina-proteasoma, influyendo así indirectamente en GP78. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | ¥451.00 | ||
Otro inhibidor del proteasoma, que podría afectar a la vía en la que interviene GP78. | ||||||