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研究者奖

2021 一月 研究者奖获得者

Wei Li

我们非常高兴地宣布 Wei Li 获得了一月 2021 研究者奖,获奖论文是

Wei Li, Jing Hu, Bi Shi, Francesco Palomba, Michelle A. Digman, Enrico Gratton & Hao Jiang: Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. Nature Cell Biology. 2020. 22:960–972. PMID: 32719551

SCBT 研究者奖获得者

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JANUARY 2021

Wei Li
Wei Li, Jing Hu, Bi Shi, Francesco Palomba, Michelle A. Digman, Enrico Gratton & Hao Jiang: Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. Nature Cell Biology. 2020. 22:960–972. PMID: 32719551

JANUARY 2020

Maiwen Caudron-Herger
Caudron-Herger M, Rusin SF, Adamo ME, Seiler J, Schmid VK, Barreau E, Kettenbach AN, Diederichs S. R-DeeP: Proteome-wide and Quantitative. Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation. Mol Cell. 2019 Jul 11;75(1):184-199. PMID: 31076284

JANUARY 2019

Sanjay Awasthi
Awasthi S, Tompkins J, Singhal J, Riggs AD, Yadav S, Wu X, Singh S, Warden C, Liu Z, Wang J, Slavin TP, Weitzel JN, Yuan YC, Awasthi M, Srivastava SK, Awasthi YC, Singhal SS. Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3918-3923. doi: 10.1073/pnas.1719586115. Epub 2018 Mar 23. PubMed PMID: 29572430; PubMed Central PMCID: PMC5899455.

JANUARY 2018

Li Jiang
Jiang L, Shao C, Wu QJ, Chen G, Zhou J, Yang B, Li H, Gou LT, Zhang Y, Wang Y, Yeo GW, Zhou Y, Fu XD. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nat Struct Mol Biol. 2017 Oct;24(10):816-824. doi: 10.1038/nsmb.3455. Epub 2017 Aug 28. PubMed PMID: 28846091.

JANUARY 2017

Marta N. Shahbazi
Shahbazi MN, Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty NM, Campbell A, Devito LG, Ilic D, Khalaf Y, Niakan KK, Fishel S, Zernicka-Goetz M. Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol. 2016 Jun;18(6):700-8. PubMed PMID: 27144686

JANUARY 2016

Nesrine Abboud
Abboud N, Moore-Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi MG, Stefanovic S, Guénantin AC, Evans SM, Pucéat M. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015 Apr 8;6:6749. PMID: 25851587

JULY 2015

Tobias Wagner
Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH. Sumoylation of HDAC2 promotes NF-κB-dependent gene expression. Oncotarget. 2015 Mar 30;6(9):7123-35. PubMed PMID: 25704882; PubMed Central PMCID: PMC4466673.

JANUARY 2015

Norman Ertych
Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L, Bastians H. Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nat Cell Biol. 2014 Aug;16(8):779-91. PubMed PMID: 24976383.

JULY 2014

Michelino Di Rosa
Di Rosa M, Tibullo D, Vecchio M, Nunnari G, Saccone S, Di Raimondo F, Malaguarnera L. Determination of chitinases family during osteoclastogenesis. Bone. 2014 Apr;61:55-63.PMID: 24440516.

JANUARY 2014

Daniel Martinez Molina
Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko, Takahiro Seki, E. Andreas Larsson, Chen Dan, Lekshmy Sreekumar, Yihai Cao, Pär Nordlund. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science. 2013 July 5;341(6141):84-87. PMID: 23828940

JULY 2013

Simona Morone
Morone S, Lo-Buono N, Parrotta R, Giacomino A, Nacci G, Brusco A, Larionov A, Ostano P, Mello-Grand M, Chiorino G, Ortolan E, Funaro A. Overexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation. PLoS One. 2012;7(8):e43649. PMID: 22916288

JANUARY 2013

Pol Margalef
Margalef P, Fernández-Majada V, Villanueva A, Garcia-Carbonell R, Iglesias M, López L, Martínez-Iniesta .M, Villà-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L. A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer. Cell Reports. 2012 October 25; 2(4):840-854. PMID: 23041317

JULY 2012

Maria Rosaria Amoroso
Amoroso MR, Matassa DS, Laudiero G, Egorova AV, Polishchuk RS, Maddalena F, Piscazzi A, Paladino S, Sarnataro D, Garbi C, Landriscina M, Esposito F. TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins. Cell Death Differ. 2012 19(4):592-604. PMID 21979464.

JANUARY 2012

Bilal Hafeez
Bilal Bin Hafeez, Weixiong Zhong, Jamey Weichert, Nancy E. Dreckschmidt, Mohammad Sarwar Jamal, Ajit K. Verma. Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res. 2011 71(6):2318-2327. PMID 21406403.

JULY 2011

Chih-Hsin Tang
Chih-Hsin Tang, Cheng-Fong Chen, Wei-Ming Chen, Yi-Chin Fong. IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells. J Biol Chem. 2011 286(13):11056-66. PMID: 21278254

JANUARY 2011

Prerna Kumar
Prerna Kumar, Renu Garg, Gevoni Bolden, Kailash N. Pandey. Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription. J Biol Chem. 2010 285(48):37521-37530. PMID: 20864529

JULY 2010

Barbara Bellei
Barbara Bellei, Vittoria Maresca, Enrica Flori, Angela Pitisci, Lionel Larue, Mauro Picardo. p38 regulates pigmentation via proteasomal degradation of tyrosinase. J Biol Chem. 2010 Mar 5;285(10):7288-99. PMID 20053998

JANUARY 2010

Pan-Yue Deng
Pan-Yue Deng, Zhaoyang Xiao, Chuanxiu Yang, Lalida Rojanathammanee, Laurel Grisanti, John Watt, Jonathan D. Geiger, Rugao Liu, James E. Porter and Saobo Lei. GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels. Neuron 2009 63(2):230-243. PMID: 19640481

JULY 2009

Richard Tomasini
Richard Tomasini, Katsuya Tsuchihara, Chiharu Tsuda, Suzanne K. Lau, Margareta Wilhelm, Alessandro Ruffini, Ming-sound Tsao, Juan L. Iovanna, Andrea Jurisicova, Gerry Melino, and Tak W. Mak. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A. 2009 106(3):797-802. PMID: 19139399

JANUARY 2009

Ning Ding
Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan and Thomas G. Boyer. Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Molecular Cell. 2008 31:347-359. PMID: 18691967

JULY 2008

Melissa R. Junttila
Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J. CIP2A inhibits PP2A in human malignancies. Cell. 2007 Jul 13;130(1):51-62. PMID: 17632056

JANUARY 2008

Kwang Seok Ahn
Ahn, K.S., Sethi, G., Krishnan, K. and Aggarwal, B.B. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. 2007.  J. Biol. Chem. 282:809-820. PMID: 17114179

JULY 2007

Young-Gun Yoo
Yoo, Y.G., Na, T.Y., Yang, W.K., Kim, H.J., Lee, I.K., Kong, G., Chung, J.H. and Lee, M.O.  2006. 6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation. Oncogene 26: 3823-3834.

JANUARY 2007

Ayyakkannu Ayyanan
Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-depedent mechanism. Proc. Natl. Acad. Sci. USA. 2006. 103:3799-3804.

JULY 2006

Vadim Budagian
Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, Bellosta P, Basilico C, Adam D, Paus R, Bulfone-Paus S. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J. 2005 Dec 21;24(24):4260-70. Epub 2005 Nov 24.

JANUARY 2006

Irina Kratchmarova
Irina Kratchmarova, Blagoy Blagoev, Mandana Haack-Sorensen, Moustapha Kassem, Matthias Mann1. Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation. Science. 2005 Jun 3; 308(5727):1472-7.

JULY 2005

Maen Abdeirahim
Abdelrahim, M., Lui, S., and Safe, S. 2005. Induction of Endoplasmic Reticulum (ER)-Induced Stress Genes in Panc-1 Pancreatic Cancer Cells is Dependent on Sp Proteins. J Biol Chem. 280(16):16508-13

JANUARY 2005

J. L. Lavrrar
Lavrrar JL and Farnham PJ. 2004. The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation. J Biol. Chem. 2004 279:46343-46349.

JULY 2004

Masako Miura
Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, LW., Robey, PG., and Shi, S. 2003. SHED: stem cells from human exfoliated deciduous teeth. PNAS USA. 100(10):5807-5812

JANUARY 2004

Sarah P. Thayer
Sarah P. Thayer, Pasca di Magliano, P., Heiser, P., Nielson, C., Roberts, D., Lauwers, G., Qi, Y., Gysin, S., Fernndez-del Castillo, C., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A., and Hebrok, M. 2003. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425:851-856

JULY 2003

Marina Macias-Silva
Marina Macias-Silva, Li, W., Leu, L.I., Crissey, S. M.A., and Taub, R. 2002. Up-regulated transcriptional repressors SnoN and Ski Bind Smad proteins to antagonize transforming growth factor- signals during liver regeneration. J. Biol. Chem. 277: 28483-28490.

JANUARY 2003

Nigel Carter
Carter, N., Nakamoto, T., Hirai, H., and Hunter, T. 2002. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat. Cell Biol. 4: 565-573.

JULY 2002

A.S. Weinmann
Weinmann, A.S., Bartley, S.M., Zhang, T., Zhang, .MQ., and Farnham, P.J. 2001. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol. Cell. Biol. 21: 6820-6832.

JANUARY 2002

Olivier Nicole
Olivier Nicole, Fabian Docagne, Carine Ali, Isabelle Margaill, Peter Carmeliet, Eric T. MacKenzie, Denis Vivien and Alain Buisson. 2001. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nature Medicine. 7: 59-64.

JULY 2001

Yan-Hong Zhang
Yan-Hong Zhang, Antoinette Heulsmann, M. Mehrdad Tondravi, Aditi Mukherjee, and Yousef Abu-Amer. 2001. Tumor Necrosis Factor- (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling Pathways. J. Biol. Chem. 276: 563-568.

JANUARY 2001

Giulia Guarguaglini
Giulia Guarguaglini, Luigina Renzi, Filippo D'Ottavio, Barbara Di Fiore, Martina Casenghi, Enrico Cundari, and Patrizia Lavia. 2000. Regulated Ran-binding Protein 1 Activity Is Required for Organization and Function of the Mitotic Spindle in Mammalian Cells in Vivo. Cell Growth & Differentiation Vol. 11: 455-465

JULY 2000

Hui Miao
Hui Miao, Elisabeth Burnett, Michael Kinch, Erin Simon, and Bingcheng Wang. 2000. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nature Cell Biology 2: 62-69.

JANUARY 2000

Hongwu Chen
Hongwu Chen, Richard J. Lin, Wen Xie, Damien Wilpitz, and Ronald M. Evans. 1999. Regulation of Hormone-Induced Hyperacetylation and Gene Activation via Acetylation of an Acetylase. Cell 98: 675-686.

JULY 1999

Jan Karlseder
Jan Karlseder, Dominique Broccoli, Yumin Dai, Stephen Hardy and Titia de Lange. 1999. p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2. Science 283: 1321-1325.

JANUARY 1999

Shoji Yamaoka
Shoji Yamaoka, Gilles Courtois, Christine Bessia, Simon T. Whiteside, Robert Weil, Fabrice Agou, Heather E. Kirk, Robert J. Kay, and Alain Isral. 1998. Complementation Cloning of NEMO, a Component of the IB Kinase Complex Essential for NF-B ActivationK. Cell 93: 1231-1240.

JULY 1998

Robin X. Luo
Robin X. Luo, Antonio A. Postigo, and Douglas C. Dean. 1998. Rb Interacts with Histone Deacetylase to Repress Transcription. Cell 92: 463-473.

JANUARY 1998

Catherine H. Regnier
Catherine H. Regnier, Ho Yeong Song, Xiong Gao, David V. Goeddel, Zhaodan Cao, and Mike Rothe. 1997. Identification and Characterization of an IB Kinase. Cell 90: 373-383.

JULY 1997

Frank S. Lee
Jeremiah Hagler, Zhigian J. Chen, and Tom Maniatis. 1997. Activation of the IB Kinase Complex by MEKK1, a Kinase of the JNK Pathway. Cell 88: 213-222.

JANUARY 1997

Daniel J. Van Antwerp
Daniel J. Van Antwerp, Seamus J. Martin, Tal Kafri, Douglas R. Green and Inder M. Verma. 1996. Suppression of TNF--induced apoptosis by NF-B. Science 274: 787-789.

JULY 1996

Shuqian Jing
Shuqian Jing, Duanzhi Wen, Yanbin Yu, Paige L. Holst, Yi Luo, Mei Fang, Rami Tamir, Laarni Antonio, Zheng Hu, Rod Cupples, Jean-Claude Louis, Sylvia Hu, Bruce W. Altrock and Gary M. Fox. 1996. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-, a novel receptor for GDNF. Cell 85: 1113-1124.

JANUARY 1996

Omar A. Coso
Omar A. Coso, Mario Chiariello, Jin-Chen Yu, Hidemi Teramoto, Piero Crespo, Ningzhi Xu, Toru Miki, and J. Silvio Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.

JULY 1995

David D. Schlaepfer
David D. Schlaepfer, Steven K. Hanks, Tony Hunter, and Peter van der Geer. 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786-791

JANUARY 1995

Ellen Freed
Ellen Freed, Marc Symons, Susan G. Macdonald, Frank McCormick, and Rosamaria Ruggieri. 1994. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265: 1713-1716.

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