EHD (EH Domain Containing) 抑制因子

The EHD (EH Domain Containing) family (EHD1, EHD2, EHD3, and EHD4) signaling refers to a group of proteins characterized by the presence of an Eps15 Homology (EH) domain. These proteins are involved in various cellular processes, especially in endocytic recycling, where they regulate the transport of internalized molecules back to the plasma membrane. EHD proteins interact with various partners, including lipids and proteins, which enables them to influence membrane curvature and trafficking dynamics. They play a critical role in the endosomal sorting complex required for transport (ESCRT) machinery, impacting cellular sorting and signaling pathways. Dysregulation of EHD signaling is associated with numerous diseases, including cancer, due to its involvement in cell proliferation and migration. Overall, EHD family proteins are vital for maintaining cellular homeostasis by regulating endocytic recycling and membrane trafficking.

EHD proteins, characterized by their EH domains, are critical for the transportation of recycled materials from endosomes to the plasma membrane, influencing various cellular processes. Inhibiting these proteins could potentially disrupt the recycling of key receptors and transporters, affecting cell signaling, nutrient uptake, and immune responses. Such targeted inhibition could provide valuable insights into the physiological functions of EHD proteins and in diseases where endocytic recycling is dysregulated, like cancer or neurodegenerative disorders.